Institutional Efficacy.

Since 2010, oxygen nanobubbles have been extensively studied at Harvard University, Oxford University, Rush and NY Medical Schools with respect to their influence on a spectrum of neurological diseases.


These results were presented at the Society for Neuroscience Annual Meeting in 2014. In December 2016, researchers from Oxford University published a study entitled “Reducing Tumor Hypoxia via Oral Administration of Oxygen Nanobubbles ” demonstrating the potential medical applications of oxygen nanobubbles.

Reducing Tumour Hypoxia via Oral Administration of Oxygen Nanobubbles

Joshua Owen1, Conor McEwan2, Heather Nesbitt2, Phurit Bovornchutichai1, Raymond Averre3, Mark Borden4, Anthony P. McHale2, John F. Callan2, Eleanor Stride1*

1 Oxford Institute of Biomedical Engineering, University of Oxford, Oxford, United Kingdom,

2 Biomedical Sciences Research Institute, Ulster University, Coleraine, Northern Ireland, United Kingdom,

3 Avrox Technologies Ltd. Copgrove, Harrogate, North Yorkshire, United Kingdom,

4 Department of Mechanical Engineering, University of Colorado, 1111 Engineering Drive, Boulder, CO, United States of America

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Stability & Existence.

In a study published in 2018 American Chemical Society, researchers from the University of Birmingham, UK finally proved with no doubt that oxygen nanobubbles exist and are very stable in water at high concentrations, approaching one billion (1,000,000,000) nanobubbles per millilitre. The results were confirmed in many laboratories, including Periphex’s, utilising analytical equipment based on DLS (dynamic light scattering).

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Alzheimer’s disease.

At the Society for Neuroscience meeting held November 15 to 19 in Washington, D.C., 2014, scientists presented surprising findings that suggest the smallest bubbles of all—nanobubbles—may boost cognition and even fight Alzheimer’s disease. The bulk of the data came from Revalesio, a small company based in Tacoma, Washington, and its collaborators.


Researchers have reported that these tiny spheres achieve all manner of cellular heroics, including soothing neuro inflammation, blocking tau phosphorylation, saving neurons from the brink of death, boosting synaptic plasticity, and even rescuing memory deficits in AD mouse models

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Clinical Evidence for therapeutic use of Nanobubbles.

Applications of Nanobubbles in Neurodegenerative Conditions

In a study performed on cellular models in mice having Amyotrophic Lateral Sclerosis (ALS, also known as Lou Gehrig’s Disease), it was demonstrated that the Nanobubbles of Oxygen have anti-inflammatory and neuro protective properties.

The authors showed that the injection of Nano bubbled saline solution slowed the disease progression through a significant protection of spinal motor neurons and neuromuscular junctions.


Clinical Studies.

Nanobubbles of O2 And CO2 are effective at reducing pain in Peripheral Neuropathy

In a prospective study in 29 patients, Dr. Jeffrey LaMour reports that repeated topical applications of water infused with Nanobubbles of Oxygen and CO2 are effective at reducing pain by at least 50% in 62.1% of patients suffering for Peripheral Neuropathy with no side effects.

Published data show that Lyrica is reducing pain by 50% or more in only 27% and Gabapentin in 40% of the patients treated.

Dr. Jeffrey LaMour presented his report at the TPMA Southwest Foot and Ankle Conference September 12-15, 2019, Frisco, TX.

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Summary of the effect of Oxygenated water.

Studies from the Pharmacology and Toxicology University of Munich

“The textbooks have to be rewritten”. We are drawing this balance in our studies about the effect of oxygenated water in the human organism.

The existing doctrines assume that the human organism absorb oxygen only by the lung and the skin. The researches of the “Walther-Straub Institute for Pharmacology and Toxicology at the University of Munich” have resulted in surprising conclusions.

Through the absorption of oxygenated water, as on a certain concentration, the organism receives additional oxygen. This oxygen delivers in the stomach, diffuses through the gastric septum, aerates the venous blood in the blood capillaries of the gastric septum and results in a high boost of oxygen in the abdominal cavity.


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Review of Oxygenation with Nanobubbles: Possible Treatment for Hypoxic COVID-19 Patients

Ronak Afshari, Omid Akhavan,* Michael R Hamblin,* and Rajender S. Varma*

Czech Advanced Technology and Research Institute, Palacky University, Šlechtitelů 27, Olomouc 78371, Czech Republic.


Laser Research Centre, Faculty of Health Science, University of Johannesburg, Doornfontein 2028, South Africa.

Department of Physics, Sharif University of Technology, P.O. Box 11155-9161, Tehran


The coronavirus disease (COVID-19) pandemic,
which has spread around the world, caused the death of many
affected patients, partly because of the lack of oxygen arising from
impaired respiration or blood circulation


The present review highlights the ever-increasing application of
nanobubbles (NBs), miniature gaseous vesicles, for the oxygenation
of hypoxic patients. Oxygen-containing NBs can exert a range of
beneficial physiologic and pharmacologic effects that include tissue
oxygenation, as well as tissue repair mechanisms, anti inflammatory
properties, and antibacterial activity.

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